Li Laboratory

Selected Publications

Ganguly SS, Daft PG, Cao J, Meng X, Zhong ZA, Vander Ark A, Meadows A, Madaj Z, Li X. Loss of myeloid-specific TGF-b signaling decreases CTHRC1 to downregulated bFGF and the development of H1993-induced osteolytic bone lesions. Cancers (2018) 10:463–477.

Vander Ark A, Li X. 2018. TGF-β receptors: in and beyond TGF- b signalingCell Signal 52:112–120.

Vander Ark A, Cao J, Li X. 2018. Mechanisms and approaches for overcoming enzalutamide resistance in prostate cancer. Frontiers in Oncololgy 8:180–188.

Meng X, Vander Ark A, Daft P, Woodford E, Wang J, Madaj Z, Li X. 2018. Loss of TGF-b signaling in osteoblasts increases basic-FGF and promotes prostate cancer bone metastasis. Cancer Letters 418:109–118.

Minciacchi VR, Spinelli C, Reis-Sobreiro M, Cavallini L, You S, Zandian M, Li X, Chiarugi P, Adam RM, Posadas EM, Viglietto G, Freeman MR, Cocucci E, Bhowmick NA, Di Vizio D. 2017. Myc mediates large oncosome-induced fibroblast reprogramming in prostate cancer. Cancer Res 77:2306–2317

Vander Ark A, Woodford E, Li X. 2016. Molecular mechanisms of therapies for prostate cancer with bone metastasis. J Explor Res Pharmacol (2016) 1:35–39.

Meng X, Vander Ark A, Lee P, Hostetter G, Bhowmick NA, Matrisian LM, Williams BO, Miranti CK, Li X. 2016. Myeloid-specific TGF-β signaling in bone promotes basic-FGF and breast cancer bone metastasis. Oncogene. 35:2370–2378.

Ganguly SS, Li X, Miranti CK. 2014. The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis. Front Oncol 4: 364.   

Banarjee J, Mishra R, Li X, Jackson RS 2nd, Sharma A, Bhowmick NA. 2014. A reciprocal role of prostate cancer on stromal DNA damageOncogene33(41):4924–4931.   

Li X, Sterling JA, Fan KH, Vessella RL, Shyr Y, Hayward SW, Matrisian LM, Bhowmick NA. 2012. Loss of TGF-beta responsiveness in prostate stromal cells alters chemokine levels and facilitates the development of mixed osteoblastic/osteolytic bone lesions. Mol Cancer Res 10(4):494–503.   

Ge L, Smail M, Meng W, Shyr Y, Ye F, Fan KH, Li X, Zhou HM, Bhowmick NA. 2011. Yes-associated protein expression in head and neck squamous cell carcinoma nodal metastasis. PLoS One 6(11):e27529.  

Kiskowski MA, Jackson RS 2nd, Banerjee J, Li X, Kang M, Iturregui JM, Franco OE, Hayward SW, Bhowmick NA. 2011. Role for stromal heterogeneity in prostate tumorigenesisCancer Res 71(10):3459–3470.  

Li X, Martinez-Ferrer M, Botta V, Uwamariya C, Banerjee J, Bhowmick NA. 2011. Epithelial Hic-5/ARA55 expression contributes to prostate tumorigenesis and castrate responsiveness. Oncogene 30(2):167–177.  

Placencio VR, Li X, Sherrill TP, Fritz G, Bhowmick NA. 2010. Bone marrow derived mesenchymal stem cells incorporate into the prostate during regrowthPLoS One 5(9): e12920.  

Li X, Wang Y, Sharif-Afshar AR, Uwamariya C, Yi A, Ishii K, Hayward SW, Matusik RJ, Bhowmick NA. 2009. Urothelial transdifferentiation to prostate epithelia is mediated by paracrine TGF-beta signalingDifferentiation 77(1): 95–102.   

Li X, Placencio V, Iturregui JM, Uwamariya C, Sharif-Afshar AR, Koyama T, Hayward SW, Bhowmick NA. 2008. Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axisOncogene 27(56): 7118–7130.   

Placencio VR, Sharif-Afshar AR, Li X, Huang H, Uwamariya C, Neilson EG, Shen MM, Matusik RJ, Hayward SW, Bhowmick NA. 2008. Stromal transforming growth factor-beta signaling mediates prostatic response to androgen ablation by paracrine Wnt activity. Cancer Res 68(12): 4709–4718.  

Li X, Kakkad B, Ong DE. 2004. Estrogen directly induces expression of retinoic acid biosynthetic enzymes, compartmentalized between the epithelium and underlying stromal cells in rat uterusEndocrinology 145(10): 4756–62.   

Li X and Ong DE. 2003. Cellular retinoic acid-binding protein II gene expression is directly induced by estrogen, but not retinoic acid, in rat uterus. Journal Biol Chem 278(37): 35819–35825.   

Li X, Zhi-jie X, Piao Y. 2002. Transforming growth factor β1 and epidermal growth factor decrease the expression of 17β-hydroxysteroid dehydrogenase type 2 in endometrial carcinoma cellsChinese Science Bulletin 47:43–46. 

Li X, Li H, Xiao ZJ, Piao YS. 2002. Divergent effects of retinoic acids on the expression of ERalpha and 17beta-hydroxysteroid dehydrogenase type 2 in endometrial carcinoma cells (RL 95-2). J Clin Endocrinol Metab 87(2):640–649.   

Li, X, Juan HW, Ling L, Gu HM, Tao YM, Zhang ZX. 1997. Inhibition effect of IM-94 on cancer cells. J Nanjing Univ 33: 311–315.